Imputation and footprinting for single cell ATAC-seq. New manuscript & software release! scOpen deals with massive sparsity and dropout events of single cell ATAC-seq. Use of scOpen improves clustering, inference of regulators and chromatin conformation. scHINT dissect regulatory & temporal …

Imputation and footprinting for single cell ATAC-seq. New manuscript & software release! Read more »

A paper describing TDF- a framework for detection of triple helix forming RNAs  – is finally out in NAR! Moreover with Grummt Lab, we have performed computational analysis of TripleRNA-seq and TriplexDNA-seq; two novel protocols for returning DNA/RNA molecules forming …

Decoding the function of lncRNAs – New computational metohd & sequencing protocols for detection of RNA-DNA Triple Helices Read more »

Together with Kurian lab, we have delineated bionformatics framework to uncover novel antisense lncRNAs during cardiomyocite differentiation. These were particularly positioned up-stream of transcription factors, and showed a high positive correlation with these anti-sense partners.In this paper, Frank and colleagues …

Decoding the function of lncRNAs – Paper in Cell Stem Cell Read more »