The Institute for Computational Genomics, RWTH Aachen University performs cutting edge research on computational and genomic methods for understanding regulatory and epigenetic processes driving cell differentiation and diseases (Gusmao, Nature Methods, 2016, Li, Genome Biology, 2019). This project aims studying RNA-DNA interactions as mechanisms of transcriptional control. We have recently shown how long-noncoding RNAs (HOTAIR, GATA6-AS, NEAT1) interacts with DNA via triple helices to control the expression of genes during cell differentiation (Kalwa et al., NAR, 2016; Kuo, NAR, 2019; Frank, Cell Stem cell, 2019).
We are looking for a phd/postdoc candidate to work on sequence analysis algorithms and statistical models for detection of RNA-DNA triple helices. This includes the analysis of novel in vitro transcription experiments and target sequencing protocols, which capture triple helix forming RNA and DNA molecules. This project will be performed in collaboration with cell biologists of RWTH Aachen, University of Cologne and University of Oslo.
Applicants should hold a M.Sc. (Ph.D.) in Bioinformatics or Computer Science. Experience in the analysis of biological sequences and regulatory genomics is required. The candidate should have solid programming skills (C, Python and/or R) and acquaintance with Unix/Linux. Experience with high performance computing is a plus. The working language of the group is English. The position is a will be initially for 3 years with possibility of extension. The salary corresponds to level 13 TV-L.
Interested candidates should send a brief statement of research interests, CV and the names of three references to firstname.lastname@example.org.